Structural insights into how 5-hydroxymethylation influences transcription factor binding.
نویسندگان
چکیده
Transcription factor binding and high resolution crystallographic studies (1.3 Å) of Dickerson-Drew duplexes with cytosine, methylcytosine and hydroxymethylcytosine bases provide evidence that C-5 cytosine modifications could regulate transcription by context dependent effects on DNA transcription factor interactions.
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عنوان ژورنال:
- Chemical communications
دوره 50 15 شماره
صفحات -
تاریخ انتشار 2014